The Neuro-Oncology Surgical Outcomes Laboratory
Projects

Glioma:  We are currently

1. defining appropriate outcome measures specific for patients with glioma;
2. studying the combination of adjuvant therapies and physiological parameters that may influence progression-free survival;
3. investigating novel radiographic measures to predict histological grade and overall survival; and
4. assessing potentially reversible risk factors of perioperative surgical morbidity in patients with glioma.

"Malignant astrocytomas involving subventricular brain regions demonstrate a more agressive behavior with increased edema, multifocal spread, and decreased post-surgical survival."

Meningioma:  We are currently

1. defining appropriate outcome measures specific for patients with meningiomas and other benign intracranial lesions;
2. investigating radiographic factors predictive of iatrogenic neurological decline;
3. studying histological characteristics predictive of tumor recurrence; and
4. assessing potentially reversible contributors of perioperative surgical morbidity in patients with meningioma.

Pituitary tumors:  We are currently

1. defining appropriate outcome measures specific for patients with pituitary tumors;
2. assessing the efficacy of novel and minimally invasive surgical treatments of pituitary tumors;
3. investigating laboratory parameters of endocrinopathy predictive of response to surgical treatment of pituitary tumors; and
4. investigating factors contributing to perioperative morbidity after surgical treatment of pituitary tumors.

Acoustic Neuroma and Cerebellar-
Pontine Angle Tumors:  We are currently

1. defining appropriate outcome measures specific for patients with cerebellar-pontine angle tumors;
2. investigating radiographic and clinical factors predictive of iatrogenic cranial nerve injury;
3. assessing the efficacy of various surgical techniques and synthetic agents in the prevention of CSF leak and pseudomeningocele formation; and
4. investigating factors contributing to perioperative morbidity after surgical treatment of posterior fossa tumors.

Acoustic Neuroma / CP Angle Tumors

Gliomas

Meningioma

Pituitary Tumors